World Alzheimer’s Day: Sant Pau Focuses on Individuals with Down Syndrome

On World Alzheimer’s Day, the aim is to raise awareness about this incurable neurodegenerative disease that primarily affects elderly individuals. However, this year, Hospital de Sant Pau has shifted its attention to a particularly vulnerable group: individuals with Down syndrome. Alzheimer’s is characterized by cognitive decline and behavioral disturbances, with recent memory loss being one … Read more

Synaptic Tau Oligomers in Alzheimer’s Disease – A Possible Culprit in the Spread of Tau Pathology throughout the Brain

Synaptic Tau Oligomers in Alzheimer's Disease - A Possible Culprit in the Spread of Tau Pathology throughout the Brain2

Synaptic Tau Oligomers in Alzheimer’s Disease – A Possible Culprit in the Spread of Tau Pathology throughout the Brain   Alzheimer’s disease is considered one of the most common causes of dementia in older individuals. Among the neuropathological features of Alzheimer’s disease (AD), the synaptic loss is the primary correlate of cognitive decline, and the … Read more

Why study sex differences in Alzheimer’s disease and in the context of Down syndrome?

Why study sex differences in Alzheimer’s disease and in the context of Down syndrome?

Why study sex differences in Alzheimer’s disease and in the context of Down syndrome? The topic of sex differences is increasingly recognized as a top priority in neurology research, particularly in the context of precision medicine and personalized care strategies. Women account for around two-thirds of patients with Alzheimer’s disease, as well as their caregivers. … Read more

The effect of different preanalytical conditions on the stability of blood biomarkers in the diagnosis of Alzheimer’s disease

Clin Chem Lab Med - Mansilla et al. 2023

Stability of plasma samples and Alzheimer’s biomarkers Alzheimer’s disease is considered one of the most common causes of dementia in the elderly. Recently, blood biomarkers: Aβ1-42, Aβ1-40 and phospho Tau181 (p-Tau181), are proving useful in the diagnosis of the disease in research studies, but their analytical stability is unknown. A joint study between the Memory … Read more

Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer’s disease in adults with Down syndrome

Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer's disease in adults with Down syndrome

Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer’s disease in adults with Down syndrome Individuals with Down syndrome are at a high risk of developing the clinical symptoms of Alzheimer’s disease in old age due to the triplicating of chromosome 21. However, the clinical diagnosis of this disease is challenging, mainly due … Read more