The Sant Pau Memory Unit publishes a new study in collaboration with the University of California San Francisco. The study examines the role of neurofilament light chain (NfL) and total tau levels in plasma for the diagnosis of frontotemporal dementia and Alzheimer’s disease. The work entitled “Plasma tau and neurofilament light in frontotemporal lobar degeneration … Read more
Alzheimer’s disease is the major cause of death in adults with Down syndrome. Thus, there is an urgent need for objective biomarkers that can improve early diagnosis and monitor progression of Alzheimer’s disease in the Down syndrome population. Our recent study, entitled “Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction … Read more
Publication in The Lancet The Lancet, a world reference journal in Medicine, publishes the article “Clinical and Biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study“, led by the Alzheimer Down Unit of the Hospital de Sant Pau and the Down Syndrome Catalan Foundation, in collaboration with researchers from the University … Read more
What are circular RNAs? RNAs are a type of molecules present in all human cells. They usually have a linear conformation. However, some species with a ring-like structure have recently been described and named “circular RNAs”, but little is known about their function. Recent studies in the field have reported changes in the levels of … Read more
The SPIN cohort The SPIN cohort (Sant Pau Initiative on Neurodegeneration) is helping us to learn many aspects about Alzheimer’s disease and other neurodegenerative diseases. A greater knowledge of these diseases brings us a little closer to an effective treatment. The participants of the SPIN cohort (patients and healthy volunteers) collaborate in the performance of … Read more
The diagnosis of Alzheimer’s disease and frontotemporal dementia or FTD can be hard. The use of biomarkers such as the levels of different proteins in the cerebrospinal fluid allows to improve the accuracy of the diagnosis. Specifically, protein levels related to the processing of amyloid precursor protein (APP) have been linked to cerebral amyloid protein … Read more