Marta Querol defends her doctoral thesis

Marta Querol Doctoral Thesis

Marta Querol Vilaseca has presented her doctoral thesis entitled “New methods of digital neuropathology applied to neurodegenerative diseases“. The thesis has been directed and tutored by Dr. Alberto Lleó, and discusses new methodologies that are useful to examine the changes that occur at the microscopic level in the brain of people with Alzheimer’s disease and … Read more

Structural changes in the brain of patients with Alzheimer’s begin 20 years before the symptoms onset

Microestructura Alzheimer - Sant Pau Memory Unit - Barcelona

Structural brain changes in Alzheimer’s disease Brain alterations in Alzheimer’s disease patients begin years before symptoms appear and a clinical diagnosis can be made. The neuroimaging team in our group has developed a technique that measures the movement of water particles in the cerebral cortex and makes it possible to detect structural changes in the … Read more

Neurofilament and total tau in plasma for the diagnosis of frontotemporal dementia and Alzheimer’s

neurofilament - illan-gala - sant pau memory unit - barcelona

The Sant Pau Memory Unit publishes a new study in collaboration with the University of California San Francisco. The study examines the role of neurofilament light chain (NfL) and total tau levels in plasma for the diagnosis of frontotemporal dementia and Alzheimer’s disease. The work entitled “Plasma tau and neurofilament light in frontotemporal lobar degeneration … Read more

NPTX2: a new biomarker of neuronal dysfunction in adults with Down syndrome

NPTX2 - Down - Belbin - Sant Pau Memory Unit

Alzheimer’s disease is the major cause of death in adults with Down syndrome. Thus, there is an urgent need for objective biomarkers that can improve early diagnosis and monitor progression of Alzheimer’s disease in the Down syndrome population. Our recent study, entitled “Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction … Read more

Circular RNAs in Alzheimer and frontotemporal dementia

Circular RNAs in Alzheimer and frontotemporal - Cervera - Sant Pau Memory Unit

What are circular RNAs? RNAs are a type of molecules present in all human cells. They usually have a linear conformation. However, some species with a ring-like structure have recently been described and named “circular RNAs”, but little is known about their function. Recent studies in the field have reported changes in the levels of … Read more

Now available our review on genetics in neurodegenerative dementias

Genetics - Clarimon - Sant Pau Memory Unit

Although there are other unmodifiable causes of dementia, the existence of family aggregation indicates that genetics play a role to a greater or lesser extent. In recent years, there have been numerous studies that have provided new information that helps to better understand the genetic component in neurodegenerative diseases. Our Research Group, together with researchers … Read more