Overlapping microstructural changes in the brain of patients with ALS and frontotemporal dementia

ELA - DFT microestructura - Sant Pau Memory Unit - Barcelona

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) Until a few years ago, amyotrophic lateral sclerosis or ALS was considered a neurodegenerative disease that caused a progressive loss of strength with preservation of intellectual functions. However, in recent years we have learned that patients with ALS can frequently present with cognitive and personality changes that … Read more Overlapping microstructural changes in the brain of patients with ALS and frontotemporal dementia

NPTX2: a new biomarker of neuronal dysfunction in adults with Down syndrome

NPTX2 - Down - Belbin - Sant Pau Memory Unit

Alzheimer’s disease is the major cause of death in adults with Down syndrome. Thus, there is an urgent need for objective biomarkers that can improve early diagnosis and monitor progression of Alzheimer’s disease in the Down syndrome population. Our recent study, entitled “Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction … Read more NPTX2: a new biomarker of neuronal dysfunction in adults with Down syndrome

Estrella Morenas defends her Doctoral Thesis

Morenas - Doctoral - Lewy

Estrella Morenas has defended today her Doctoral Thesis entitled “Multimodal biomarkers studies in the continuum Dementia with Lewy bodies – Alzheimer’s disease“. The academical act of defense of her doctoral thesis has taken place at the Hospital de Sant Pau. This work, directed by Dr. Alberto Lleó and Dr. Juan Fortea, deepens into clinical aspects … Read more Estrella Morenas defends her Doctoral Thesis

SPIN cohort: these are the details of the study protocol

SPIN cohort

The SPIN cohort The SPIN cohort (Sant Pau Initiative on Neurodegeneration) is helping us to learn many aspects about Alzheimer’s disease and other neurodegenerative diseases. A greater knowledge of these diseases brings us a little closer to an effective treatment. The participants of the SPIN cohort (patients and healthy volunteers) collaborate in the performance of … Read more SPIN cohort: these are the details of the study protocol

Amyloid protein in patients with frontotemporal dementia

Illán-Gala, APP, frontotemporal - Sant Pau Memory Unit - Barcelona

The diagnosis of Alzheimer’s disease and frontotemporal dementia or FTD can be hard. The use of biomarkers such as the levels of different proteins in the cerebrospinal fluid allows to improve the accuracy of the diagnosis. Specifically, protein levels related to the processing of amyloid precursor protein (APP) have been linked to cerebral amyloid protein … Read more Amyloid protein in patients with frontotemporal dementia

Laura Cervera defends her doctoral thesis

CNV mitochondrial DNA and microRNA - Laura Cervera

Laura Cervera has defended her doctoral thesis today The thesis, entitled “Assessing the role of copy number variations, mitochondrial DNA and microRNAs in neurodegenerative disorders” has been directed by Dr. Jordi Clarimón and tutored by Dr. Alberto Lleó. In her work, Laura Cervera describes some markers of genetic origin that could be useful in neurodegenerative … Read more Laura Cervera defends her doctoral thesis