NPTX2: a new biomarker of neuronal dysfunction in adults with Down syndrome

NPTX2 - Down - Belbin - Sant Pau Memory Unit

Alzheimer’s disease is the major cause of death in adults with Down syndrome. Thus, there is an urgent need for objective biomarkers that can improve early diagnosis and monitor progression of Alzheimer’s disease in the Down syndrome population. Our recent study, entitled “Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction … Read more

Publication in The Lancet: natural history of Alzheimer’s disease in people with Down syndrome

Down - Sant Pau Memory Unit - The Lancet

Publication in The Lancet The Lancet, a world reference journal in Medicine, publishes the article “Clinical and Biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study“, led by the Alzheimer Down Unit of the Hospital de Sant Pau and the Down Syndrome Catalan Foundation, in collaboration with researchers from the University … Read more

Circular RNAs in Alzheimer and frontotemporal dementia

Circular RNAs in Alzheimer and frontotemporal - Cervera - Sant Pau Memory Unit

What are circular RNAs? RNAs are a type of molecules present in all human cells. They usually have a linear conformation. However, some species with a ring-like structure have recently been described and named “circular RNAs”, but little is known about their function. Recent studies in the field have reported changes in the levels of … Read more

Estrella Morenas defends her Doctoral Thesis

Morenas - Doctoral - Lewy

Estrella Morenas has defended today her Doctoral Thesis entitled “Multimodal biomarkers studies in the continuum Dementia with Lewy bodies – Alzheimer’s disease“. The academical act of defense of her doctoral thesis has taken place at the Hospital de Sant Pau. This work, directed by Dr. Alberto Lleó and Dr. Juan Fortea, deepens into clinical aspects … Read more

SPIN cohort: these are the details of the study protocol

SPIN cohort

The SPIN cohort The SPIN cohort (Sant Pau Initiative on Neurodegeneration) is helping us to learn many aspects about Alzheimer’s disease and other neurodegenerative diseases. A greater knowledge of these diseases brings us a little closer to an effective treatment. The participants of the SPIN cohort (patients and healthy volunteers) collaborate in the performance of … Read more

Amyloid protein in patients with frontotemporal dementia

Illán-Gala, APP, frontotemporal - Sant Pau Memory Unit - Barcelona

The diagnosis of Alzheimer’s disease and frontotemporal dementia or FTD can be hard. The use of biomarkers such as the levels of different proteins in the cerebrospinal fluid allows to improve the accuracy of the diagnosis. Specifically, protein levels related to the processing of amyloid precursor protein (APP) have been linked to cerebral amyloid protein … Read more