What is the value of brain atrophy in frontotemporal dementia?

Atrophy - Illán-Gala - FTD - Sant Pau Memory Unit Barcelona

Atrophy and frontotemporal dementia The behavioral variant of frontotemporal dementia is a frequent cause of neurodegenerative dementia and the first cause of Frontotemporal Lobular Degeneration. Patients with the behavioral variant of frontotemporal dementia present a progressive personality change that begins years before diagnosis and can be confused with other neurodegenerative and psychiatric diseases. Identifying atrophy … Read more

Structural changes in the brain of patients with Alzheimer’s begin 20 years before the symptoms onset

Microestructura Alzheimer - Sant Pau Memory Unit - Barcelona

Structural brain changes in Alzheimer’s disease Brain alterations in Alzheimer’s disease patients begin years before symptoms appear and a clinical diagnosis can be made. The neuroimaging team in our group has developed a technique that measures the movement of water particles in the cerebral cortex and makes it possible to detect structural changes in the … Read more

Neurofilament and total tau in plasma for the diagnosis of frontotemporal dementia and Alzheimer’s

neurofilament - illan-gala - sant pau memory unit - barcelona

The Sant Pau Memory Unit publishes a new study in collaboration with the University of California San Francisco. The study examines the role of neurofilament light chain (NfL) and total tau levels in plasma for the diagnosis of frontotemporal dementia and Alzheimer’s disease. The work entitled “Plasma tau and neurofilament light in frontotemporal lobar degeneration … Read more

Overlapping microstructural changes in the brain of patients with ALS and frontotemporal dementia

ELA - DFT microestructura - Sant Pau Memory Unit - Barcelona

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) Until a few years ago, amyotrophic lateral sclerosis or ALS was considered a neurodegenerative disease that caused a progressive loss of strength with preservation of intellectual functions. However, in recent years we have learned that patients with ALS can frequently present with cognitive and personality changes that … Read more

NPTX2: a new biomarker of neuronal dysfunction in adults with Down syndrome

NPTX2 - Down - Belbin - Sant Pau Memory Unit

Alzheimer’s disease is the major cause of death in adults with Down syndrome. Thus, there is an urgent need for objective biomarkers that can improve early diagnosis and monitor progression of Alzheimer’s disease in the Down syndrome population. Our recent study, entitled “Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction … Read more

Characterization of the transcriptome of the motor cortex in amyotrophic lateral sclerosis

Transcriptoma - ELA - Sant Pau Memory Unit - Barcelona

What is the transcriptome and why the motor cortex? The transcriptome is a set of tens of thousands of molecules called RNAs that have a key role in the formation of proteins and, therefore, in the response to pathological processes in the body. On the other hand, the motor cortex is the region of the … Read more