Biomarkers for the diagnosis of Alzheimer’s disease The characteristic symptoms of Alzheimer’s disease, such as progressive memory loss or other cognitive deficits and behavioral disorders, can make us suspect the diagnosis of this disease. This suspicion can be supported by the determination of biomarkers. Biomarkers measure the biological changes that occur in the brains of … Read moreHow do Alzheimer’s biomarkers change over time?
Non-fibrillar amyloid-β (Aβ) plaques are considered to be a critical component of Alzheimer’s disease. Characterization of these species comes mainly from studies in cellular or animal models, but there is little data in intact human samples due to the lack of adequate optical microscopic resolution to study these small structures. Marta Querol-Vilaseca in collaboration with … Read moreSuper-resolution is here for amyloid plaques
The behavioral variant of frontotemporal dementia is a neurodegenerative syndrome characterized by a progressive personality change. Given that patients maintain their cognitive abilities relatively intact in the early stages of the disease, the diagnosis requires both a thorough clinical evaluation and biomarkers to support the diagnosis of a neurodegenerative disease. Ignacio Illán Gala and Victor … Read moreIn our recent publication, we analyze cortical microstructure in frontotemporal dementia
Obesity and Alzheimer It has been established that middle-age obesity is a risk factor for Alzheimer’s disease, but the results from studies in older people are contradictory. Our recent study would explain the discrepancies on this topic. This work is the result of a collaborative effort between the Neuroimage team of the Sant Pau Memory … Read moreIs obesity a risk factor for Alzheimer’s disease?
The Sant Pau Memory Unit has published in the Journal of Neurology, Neurosurgery and Psychiatry the results of a collaborative study with researchers from University of Pennsylvania (Penn FTD Center) that characterize two markers of frontotemporal degeneration. Frontotemporal degeneration Frontotemporal degeneration causes progressive behavioural changes and/or language impairment. Sometimes, it is associated with motor problems such as parkinsonism … Read moreOur recent study in collaboration with University of Pennsylvania characterizes two markers of frontotemporal degeneration
The Department of Neurology of Hospital de Sant Pau has published in Neurology the article “CSF sAPPβ, YKL-40, and NfL along the ALS-FTD spectrum”. This study has been carried out by the Sant Pau Memory Unit and the Neuromuscular Disorders Unit of the Department of Neurology to investigate the clinical utility of cerebrospinal fluid markers in the … Read moreMarkers for amyotrophic lateral sclerosis and frontotemporal degeneration