Amyloid protein in patients with frontotemporal dementia

Illán-Gala, APP, frontotemporal - Sant Pau Memory Unit - Barcelona

The diagnosis of Alzheimer’s disease and frontotemporal dementia or FTD can be hard. The use of biomarkers such as the levels of different proteins in the cerebrospinal fluid allows to improve the accuracy of the diagnosis. Specifically, protein levels related to the processing of amyloid precursor protein (APP) have been linked to cerebral amyloid protein … Read more Amyloid protein in patients with frontotemporal dementia

The Sant Pau Memory Unit validates a technique for the early detection of Alzheimer’s

Detección Precoz Alzheimer - Sant Pau Memory Unit - Barcelona

The Sant Pau Memory Unit has published a study that establishes reference values ​​for a technique that allows the early detection of Alzheimer’s disease. This technique detects alterations in disease-related proteins in the cerebrospinal fluid of patients by means of an automated analysis. The study entitled “Agreement of Amyloid PET and CSF Biomarkers for Alzheimer’s … Read more The Sant Pau Memory Unit validates a technique for the early detection of Alzheimer’s

How do Alzheimer’s biomarkers change over time?

Longitudinal Alzheimer Biomarkers - Sant Pau Memory Unit - Barcelona

Biomarkers for the diagnosis of Alzheimer’s disease The characteristic symptoms of Alzheimer’s disease, such as progressive memory loss or other cognitive deficits and behavioral disorders, can make us suspect the diagnosis of this disease. This suspicion can be supported by the determination of biomarkers. Biomarkers measure the biological changes that occur in the brains of … Read more How do Alzheimer’s biomarkers change over time?

Super-resolution is here for amyloid plaques

Amyloid Plaque - Sant Pau Mamory Unit - Barcelona

Non-fibrillar amyloid-β (Aβ) plaques are considered to be a critical component of Alzheimer’s disease. Characterization of these species comes mainly from studies in cellular or animal models, but there is little data in intact human samples due to the lack of adequate optical microscopic resolution to study these small structures. Marta Querol-Vilaseca in collaboration with … Read more Super-resolution is here for amyloid plaques

In our recent publication, we analyze cortical microstructure in frontotemporal dementia

Brain - Illan - Sant Pau Memory Unit - Barcelona

The behavioral variant of frontotemporal dementia is a neurodegenerative syndrome characterized by a progressive personality change. Given that patients maintain their cognitive abilities relatively intact in the early stages of the disease, the diagnosis requires both a thorough clinical evaluation and biomarkers to support the diagnosis of a neurodegenerative disease. Ignacio Illán Gala and Victor … Read more In our recent publication, we analyze cortical microstructure in frontotemporal dementia

Is obesity a risk factor for Alzheimer’s disease?

Obesity and Alzheimer - Sant Pau Memory Unit - Alzheimer Research - Barcelona

Obesity and Alzheimer It has been established that middle-age obesity is a risk factor for Alzheimer’s disease, but the results from studies in older people are contradictory. Our recent study would explain the discrepancies on this topic. This work is the result of a collaborative effort between the Neuroimage team of the Sant Pau Memory … Read more Is obesity a risk factor for Alzheimer’s disease?