What is the value of brain atrophy in frontotemporal dementia?
Atrophy and frontotemporal dementia The behavioral variant of frontotemporal dementia is a frequent cause of neurodegenerative dementia and the first cause of Frontotemporal Lobular Degeneration. Patients with the behavioral variant of frontotemporal dementia present...
Marta Querol defends her doctoral thesis
Marta Querol Vilaseca has presented her doctoral thesis entitled “New methods of digital neuropathology applied to neurodegenerative diseases“. The thesis has been directed and tutored by Dr. Alberto Lleó, and discusses new methodologies that are useful to...
Structural changes in the brain of patients with Alzheimer’s begin 20 years before the symptoms onset
Structural brain changes in Alzheimer’s disease Brain alterations in Alzheimer’s disease patients begin years before symptoms appear and a clinical diagnosis can be made. The neuroimaging team in our group has developed a technique that measures the...
Neurofilament and total tau in plasma for the diagnosis of frontotemporal dementia and Alzheimer’s
The Sant Pau Memory Unit publishes a new study in collaboration with the University of California San Francisco. The study examines the role of neurofilament light chain (NfL) and total tau levels in plasma for the diagnosis of frontotemporal dementia and...
Overlapping microstructural changes in the brain of patients with ALS and frontotemporal dementia
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) Until a few years ago, amyotrophic lateral sclerosis or ALS was considered a neurodegenerative disease that caused a progressive loss of strength with preservation of intellectual functions....
NPTX2: a new biomarker of neuronal dysfunction in adults with Down syndrome
Alzheimer’s disease is the major cause of death in adults with Down syndrome. Thus, there is an urgent need for objective biomarkers that can improve early diagnosis and monitor progression of Alzheimer’s disease in the Down syndrome population. Our recent study,...
Characterization of the transcriptome of the motor cortex in amyotrophic lateral sclerosis
What is the transcriptome and why the motor cortex? The transcriptome is a set of tens of thousands of molecules called RNAs that have a key role in the formation of proteins and, therefore, in the response to pathological processes in the body. On the other hand, the...
Publication in The Lancet: natural history of Alzheimer’s disease in people with Down syndrome
Publication in The Lancet The Lancet, a world reference journal in Medicine, publishes the article “Clinical and Biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study“, led by the Alzheimer Down Unit of the...