The effect of different preanalytical conditions on the stability of blood biomarkers in the diagnosis of Alzheimer’s disease

Clin Chem Lab Med - Mansilla et al. 2023

Stability of plasma samples and Alzheimer’s biomarkers Alzheimer’s disease is considered one of the most common causes of dementia in the elderly. Recently, blood biomarkers: Aβ1-42, Aβ1-40 and phospho Tau181 (p-Tau181), are proving useful in the diagnosis of the disease in research studies, but their analytical stability is unknown. A joint study between the Memory … Read more

Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer’s disease in adults with Down syndrome

Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer's disease in adults with Down syndrome

Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer’s disease in adults with Down syndrome Individuals with Down syndrome are at a high risk of developing the clinical symptoms of Alzheimer’s disease in old age due to the triplicating of chromosome 21. However, the clinical diagnosis of this disease is challenging, mainly due … Read more

GFAP in plasma and CSF in Down syndrome and Alzheimer’s disease

gfap - Sant Pau Memory Unit - Montoliu-Gaia - Alcolea

Alzheimer’s Disease, Down Syndrome and GFAP People with Down syndrome are at higher risk of developing Alzheimer’s disease than the general population. In fact, by the age of 70, more than 95% of people with Down syndrome will develop Alzheimer’s disease, which is the leading cause of death in this population. This strong association is … Read more

Welcome to the team

Welcome! We would like to welcome the new members to the Memory Unit.     Benjamin Buehner, is a german-canadian student who did his undergraduate degree in Biomedical Sciences at Queen’s University, in Canada. He is experienced on Sclerosis and Gut-Brain-Axis research.   Natalia López is from Albacete. She studied her Bachelor’s degree in Psychology … Read more

Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist

blood-based biomarkers in neurodegenerative diseases

Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and frontotemporal dementia, are a growing health concern worldwide, and their diagnosis and management are still challenging. However, recent advances in blood-based biomarkers offer new opportunities for clinical evaluation and monitoring of these diseases. In this review article, entitled “Blood Biomarkers in Neurodegenerative Diseases: Implications for the … Read more

Amyloid precursor protein βCTF accumulates in synapses in sporadic and genetic forms of Alzheimer’s disease

Amyloid precursor protein βCTF accumulates in synapses in sporadic and genetic forms of Alzheimer’s disease

Amyloid precursor protein βCTF accumulates in synapses in sporadic and genetic forms of Alzheimer’s disease The main pathological features observed in a brain with Alzheimer’s disease (AD) are the accumulation of β-amyloid (Aβ) peptides in the form of plaques and the aggregation of phosphorylated tau protein. Amyloid precursor protein (APP) can be processed via the amyloidogenic … Read more