Frontotemporal dementia

Women show greater capacity to compensate for brain damage in cases of genetic frontotemporal dementia

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Frontotemporal dementia (FTD) encompasses a diverse group of neurodegenerative diseases characterized by progressive deterioration in social behavior, language, and executive functions. This condition has a strong genetic basis, with up to 30% of affected individuals carrying autosomal dominant mutations. Sex has gained importance in neurodegenerative research, especially in Alzheimer’s disease, where evidence shows that, together … Read more

Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist

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blood-based biomarkers in neurodegenerative diseases

Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and frontotemporal dementia, are a growing health concern worldwide, and their diagnosis and management are still challenging. However, recent advances in blood-based biomarkers offer new opportunities for clinical evaluation and monitoring of these diseases. In this review article, entitled “Blood Biomarkers in Neurodegenerative Diseases: Implications for the … Read more

GFAP in blood helps predict the evolution of frontotemporal dementia

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GFAP and frontotemporal dementia Frontotemporal dementia is a heterogeneous entity with variable clinical manifestations. As a consequence, it can be confused with psychiatric diseases or other neurodegenerative diseases such as Alzheimer’s disease. Despite the advances in the diagnosis of frontotemporal dementia in the last two decades, we still do not have a precise marker for … Read more

Neurofilament and total tau in plasma for the diagnosis of frontotemporal dementia and Alzheimer’s

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neurofilament - illan-gala - sant pau memory unit - barcelona

The Sant Pau Memory Unit publishes a new study in collaboration with the University of California San Francisco. The study examines the role of neurofilament light chain (NfL) and total tau levels in plasma for the diagnosis of frontotemporal dementia and Alzheimer’s disease. The work entitled “Plasma tau and neurofilament light in frontotemporal lobar degeneration … Read more

Overlapping microstructural changes in the brain of patients with ALS and frontotemporal dementia

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ELA - DFT microestructura - Sant Pau Memory Unit - Barcelona

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) Until a few years ago, amyotrophic lateral sclerosis or ALS was considered a neurodegenerative disease that caused a progressive loss of strength with preservation of intellectual functions. However, in recent years we have learned that patients with ALS can frequently present with cognitive and personality changes that … Read more

Circular RNAs in Alzheimer and frontotemporal dementia

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Circular RNAs in Alzheimer and frontotemporal - Cervera - Sant Pau Memory Unit

What are circular RNAs? RNAs are a type of molecules present in all human cells. They usually have a linear conformation. However, some species with a ring-like structure have recently been described and named “circular RNAs”, but little is known about their function. Recent studies in the field have reported changes in the levels of … Read more