Microscopy - Sant Pau Memory Unit

Enhanced Resolution to Study Synaptic Tau Pathology in Alzheimer’s Disease

28/11/202510/03/2025 by Sant Pau Memory Unit

Our recent study shows that combining Array Tomography with an advanced imaging technique called Two-Colour Direct Stochastic Optical Reconstruction Microscopy (dSTORM) allows for the observation of tau pathology at synapses with unprecedented detail. This approach offers new insights into how these proteins disrupt brain function in Alzheimer’s disease (AD). What Was Done in This Study? … Read more

Marta Querol defends her doctoral thesis

10/12/2020 by Sant Pau Memory Unit

Marta Querol Vilaseca has presented her doctoral thesis entitled “New methods of digital neuropathology applied to neurodegenerative diseases“. The thesis has been directed and tutored by Dr. Alberto Lleó, and discusses new methodologies that are useful to examine the changes that occur at the microscopic level in the brain of people with Alzheimer’s disease and … Read more

Super-resolution is here for amyloid plaques

28/11/202508/04/2019 by Sant Pau Memory Unit

Amyloid Plaque - Sant Pau Mamory Unit - Barcelona

Non-fibrillar amyloid-β (Aβ) plaques are considered to be a critical component of Alzheimer’s disease. Characterization of these species comes mainly from studies in cellular or animal models, but there is little data in intact human samples due to the lack of adequate optical microscopic resolution to study these small structures. Marta Querol-Vilaseca in collaboration with … Read more

Martí Colom-Cadena receives the Doctoral Thesis Extraordinary Award

28/11/202528/09/2018 by Sant Pau Memory Unit

Martí Colom-Cadena - Doctoral Thesis - Sant Pau Memory Unit - Alzheimer Research - Barcelona

Dr. Martí Colom-Cadena has received the Extraordinary Award for his doctoral thesis in Biomedicine entitled “Neuropathology of Lewy body diseases: confluence of multiple pathologies and role of synaptic phospho-alpha-synuclein“, defended at the University of Barcelona in June 2017. In his doctoral thesis, jointly directed by Dr. Alberto Lleó and Dr. Ellen Gelpí and tutored by … Read more

Publication of Sant Pau Memory Unit in Brain

28/11/202523/11/2017 by Sant Pau Memory Unit

Brain - Lewy body disease - Alpha-synuclein - Sant Pau Memory Unit - Barcelona

The Sant Pau Memory Unit has published a paper describing the detection of phosphorilated alpha-synuclein in the synapses of Lewy body dementia patients this week in Brain.