Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum

“Clinical dimensions along the nonfluent variant primary progressive aphasia spectrum” Dr. Ignacio Illán Gala is a Neurologist at the memory unit of the Hospital de la Santa Creu i Sant Pau. He currently leads the research group focused on the “Natural history, diagnosis and treatment of Frontotemporal Lobar Degeneration”. Other clinical researchers from our center … Read more

Synaptic Tau Oligomers in Alzheimer’s Disease – A Possible Culprit in the Spread of Tau Pathology throughout the Brain

Synaptic Tau Oligomers in Alzheimer's Disease - A Possible Culprit in the Spread of Tau Pathology throughout the Brain2

Synaptic Tau Oligomers in Alzheimer’s Disease – A Possible Culprit in the Spread of Tau Pathology throughout the Brain   Alzheimer’s disease is considered one of the most common causes of dementia in older individuals. Among the neuropathological features of Alzheimer’s disease (AD), the synaptic loss is the primary correlate of cognitive decline, and the … Read more

Why study sex differences in Alzheimer’s disease and in the context of Down syndrome?

Why study sex differences in Alzheimer’s disease and in the context of Down syndrome?

Why study sex differences in Alzheimer’s disease and in the context of Down syndrome? The topic of sex differences is increasingly recognized as a top priority in neurology research, particularly in the context of precision medicine and personalized care strategies. Women account for around two-thirds of patients with Alzheimer’s disease, as well as their caregivers. … Read more

Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer’s disease in adults with Down syndrome

Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer's disease in adults with Down syndrome

Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer’s disease in adults with Down syndrome Individuals with Down syndrome are at a high risk of developing the clinical symptoms of Alzheimer’s disease in old age due to the triplicating of chromosome 21. However, the clinical diagnosis of this disease is challenging, mainly due … Read more

Amyloid precursor protein βCTF accumulates in synapses in sporadic and genetic forms of Alzheimer’s disease

Amyloid precursor protein βCTF accumulates in synapses in sporadic and genetic forms of Alzheimer’s disease

Amyloid precursor protein βCTF accumulates in synapses in sporadic and genetic forms of Alzheimer’s disease The main pathological features observed in a brain with Alzheimer’s disease (AD) are the accumulation of β-amyloid (Aβ) peptides in the form of plaques and the aggregation of phosphorylated tau protein. Amyloid precursor protein (APP) can be processed via the amyloidogenic … Read more