Synaptic Proteins VAMP-2 and SNAP-25 as Biomarkers in Dementia with Lewy Bodies

Dementia with Lewy bodies (DLB) is one of the leading causes of dementia, yet clear biomarkers for its diagnosis and monitoring are still lacking. The Lewy bodies in the brains of people with DLB are primarily composed of accumulations of the protein α-synuclein, which can cause synaptic dysfunction from the early stages of the disease. … Read more

Awarded with the SEN 2023 Prizes

Dr. Juan Fortea Ormaechea, director of the Memory Unit at Sant Pau Hospital, has been awarded the Scientific Modality Prize in the Alzheimer’s category during the Institutional Act of the Spanish Society of Neurology (SEN), held on June 6, 2024, at the Fonseca College of Santiago de Compostela. This prestigious recognition underscores Dr. Fortea’s world-class … Read more

Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum

“Clinical dimensions along the nonfluent variant primary progressive aphasia spectrum” Dr. Ignacio Illán Gala is a Neurologist at the memory unit of the Hospital de la Santa Creu i Sant Pau. He currently leads the research group focused on the “Natural history, diagnosis and treatment of Frontotemporal Lobar Degeneration”. Other clinical researchers from our center … Read more

Synaptic Tau Oligomers in Alzheimer’s Disease – A Possible Culprit in the Spread of Tau Pathology throughout the Brain

Synaptic Tau Oligomers in Alzheimer's Disease - A Possible Culprit in the Spread of Tau Pathology throughout the Brain2

Synaptic Tau Oligomers in Alzheimer’s Disease – A Possible Culprit in the Spread of Tau Pathology throughout the Brain   Alzheimer’s disease is considered one of the most common causes of dementia in older individuals. Among the neuropathological features of Alzheimer’s disease (AD), the synaptic loss is the primary correlate of cognitive decline, and the … Read more

Why study sex differences in Alzheimer’s disease and in the context of Down syndrome?

Why study sex differences in Alzheimer’s disease and in the context of Down syndrome?

Why study sex differences in Alzheimer’s disease and in the context of Down syndrome? The topic of sex differences is increasingly recognized as a top priority in neurology research, particularly in the context of precision medicine and personalized care strategies. Women account for around two-thirds of patients with Alzheimer’s disease, as well as their caregivers. … Read more