Myelin loss in C9orf72 hexanucleotide expansion carriers

Myelin loss in C9orf72 hexanucleotide expansion carriers   The expansion of the intronic GGGGCC repeat (G4C2) in the C9orf72 gene is the most common genetic cause of Frontotemporal Dementia (FTD), Amyotrophic Lateral Sclerosis (ALS) and in the continuum of FTD/ALS. Three pathological mechanisms associated with the presence of this genetic alteration have been described: a … Read more

The link between Alzheimer’s disease and Down syndrome

Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome

The link between Alzheimer’s disease and Down syndrome People with Down syndrome are genetically predisposed to developing Alzheimer´s disease. The strong association between Alzheimer disease and Down syndrome has a genetic basis through a gene-dose effect of the amyloid precursor protein (APP) gene located on chromosome 21, which is triplicated in this population. Consequently, neuropathologic changes associated with … Read more

New plasma biomarker to detect Alzheimer’s disease in Down syndrome individuals

Down Alzheimer - Plasma Markers - APOE

Plasma biomarkers Scientists worldwide are immersed in the race for accurate, non-invasive and accessible biomarkers to detect and diagnose Alzheimer’s Disease. To date, major scientific advances allowed the identification of several biomarkers in cerebrospinal fluid or using positron emission tomography (PET). Yet, these methods are either invasive or expensive and not easily accessible to all … Read more

Dr. Oriol Dols-Icardo, awarded by Fundación hna

Fundación hna - Oriol Dols-Icardo - Sant Pau Memory Unit

Research award by Fundación hna Fundación hna has awarded Dr. Oriol Dols-Icardo the prize of the first edition of the “Premio de Investigación Científica de Salud“. This is a competitive call for funding a research project on Amyotrophic Lateral Sclerosis (ALS), in which a total of 19 proposals have been submitted. The project funded by … Read more

Characterization of the transcriptome of the motor cortex in amyotrophic lateral sclerosis

Transcriptoma - ELA - Sant Pau Memory Unit - Barcelona

What is the transcriptome and why the motor cortex? The transcriptome is a set of tens of thousands of molecules called RNAs that have a key role in the formation of proteins and, therefore, in the response to pathological processes in the body. On the other hand, the motor cortex is the region of the … Read more

Circular RNAs in Alzheimer and frontotemporal dementia

Circular RNAs in Alzheimer and frontotemporal - Cervera - Sant Pau Memory Unit

What are circular RNAs? RNAs are a type of molecules present in all human cells. They usually have a linear conformation. However, some species with a ring-like structure have recently been described and named “circular RNAs”, but little is known about their function. Recent studies in the field have reported changes in the levels of … Read more