Characterization of the transcriptome of the motor cortex in amyotrophic lateral sclerosis
What is the transcriptome and why the motor cortex? The transcriptome is a set of tens of thousands of molecules called RNAs that have a key role in the formation of proteins and, therefore, in the response to pathological processes in the body. On the other hand, the...
Publication in The Lancet: natural history of Alzheimer’s disease in people with Down syndrome
Publication in The Lancet The Lancet, a world reference journal in Medicine, publishes the article “Clinical and Biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study“, led by the Alzheimer Down Unit of the...
Now available our review on genetics in neurodegenerative dementias
Although there are other unmodifiable causes of dementia, the existence of family aggregation indicates that genetics play a role to a greater or lesser extent. In recent years, there have been numerous studies that have provided new information that helps to better...
SPIN cohort: these are the details of the study protocol
The SPIN cohort The SPIN cohort (Sant Pau Initiative on Neurodegeneration) is helping us to learn many aspects about Alzheimer’s disease and other neurodegenerative diseases. A greater knowledge of these diseases brings us a little closer to an effective...
Amyloid protein in patients with frontotemporal dementia
The diagnosis of Alzheimer’s disease and frontotemporal dementia or FTD can be hard. The use of biomarkers such as the levels of different proteins in the cerebrospinal fluid allows to improve the accuracy of the diagnosis. Specifically, protein levels related...
Laura Cervera defends her doctoral thesis
Laura Cervera has defended her doctoral thesis today The thesis, entitled “Assessing the role of copy number variations, mitochondrial DNA and microRNAs in neurodegenerative disorders” has been directed by Dr. Jordi Clarimón and tutored by Dr. Alberto...
The Sant Pau Memory Unit validates a technique for the early detection of Alzheimer’s
The Sant Pau Memory Unit has published a study that establishes reference values for a technique that allows the early detection of Alzheimer’s disease. This technique detects alterations in disease-related proteins in the cerebrospinal fluid of patients by...
How do Alzheimer’s biomarkers change over time?
Biomarkers for the diagnosis of Alzheimer’s disease The characteristic symptoms of Alzheimer’s disease, such as progressive memory loss or other cognitive deficits and behavioral disorders, can make us suspect the diagnosis of this disease. This suspicion...