The Sant Pau Memory Unit has published a study that establishes reference values for a technique that allows the early detection of Alzheimer’s disease. This technique detects alterations in disease-related proteins in the cerebrospinal fluid of patients by means of an automated analysis. The study entitled “Agreement of Amyloid PET and CSF Biomarkers for Alzheimer’s … Read more
Biomarkers for the diagnosis of Alzheimer’s disease The characteristic symptoms of Alzheimer’s disease, such as progressive memory loss or other cognitive deficits and behavioral disorders, can make us suspect the diagnosis of this disease. This suspicion can be supported by the determination of biomarkers. Biomarkers measure the biological changes that occur in the brains of … Read more
Non-fibrillar amyloid-β (Aβ) plaques are considered to be a critical component of Alzheimer’s disease. Characterization of these species comes mainly from studies in cellular or animal models, but there is little data in intact human samples due to the lack of adequate optical microscopic resolution to study these small structures. Marta Querol-Vilaseca in collaboration with … Read more
The behavioral variant of frontotemporal dementia is a neurodegenerative syndrome characterized by a progressive personality change. Given that patients maintain their cognitive abilities relatively intact in the early stages of the disease, the diagnosis requires both a thorough clinical evaluation and biomarkers to support the diagnosis of a neurodegenerative disease. Ignacio Illán Gala and Victor … Read more
Obesity and Alzheimer It has been established that middle-age obesity is a risk factor for Alzheimer’s disease, but the results from studies in older people are contradictory. Our recent study would explain the discrepancies on this topic. This work is the result of a collaborative effort between the Neuroimage team of the Sant Pau Memory … Read more
The Sant Pau Memory Unit has published in the Journal of Neurology, Neurosurgery and Psychiatry the results of a collaborative study with researchers from University of Pennsylvania (Penn FTD Center) that characterize two markers of frontotemporal degeneration. Frontotemporal degeneration Frontotemporal degeneration causes progressive behavioural changes and/or language impairment. Sometimes, it is associated with motor problems such as parkinsonism … Read more