The Sant Pau Memory Unit has published a paper describing the detection of phosphorilated alpha-synuclein in the synapses of Lewy body dementia patients this week in Brain.
This work, first authored by Dr. Martí Colom-Cadena and led by Dr. Alberto Lleó, is entitled “Synaptic phosphorylated α-synuclein in dementia with Lewy bodies” and is the result of a collaboration between the Sant Pau Memory Unit, Institut de Ciències Fotòniques de Catalunya (ICFO), the Harvard University and the University of Edinburgh.
In this article, we describe the detection of phosphorilated alpha-synuclein in the synapses of brains from patients with Lewy body dementia. This detection has been possible by using a new microscopy technique known as array tomography, that combines ultrathin sections with immunofluorescence and allows the observation and quantification of small-sized structures.
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