Dr. Martí Colom-Cadena has received the Extraordinary Award for his doctoral thesis in Biomedicine entitled “Neuropathology of Lewy body diseases: confluence of multiple pathologies and role of synaptic phospho-alpha-synuclein“, defended at the University of Barcelona in June 2017.
In his doctoral thesis, jointly directed by Dr. Alberto Lleó and Dr. Ellen Gelpí and tutored by Dr. Isidre Ferrer, Dr. Colom-Cadena applied a novel technique of microscopy, “Array tomography“, based on 70 nanometer-wide serial cut-offs, to study protein deposits and their relationship with the synapses in Lewy bodies diseases.
The results of his work, confirm that in dementia with Lewy bodies, characterized by alpha-synuclein deposits, is common the presence of co-pathologies, that is, accumulation of other proteins in the brain. It also describes a correlation between beta-amyloid and alpha-synuclein aggregates, suggesting a local synergy between them.
Currently, Dr. Colom-Cadena courses a postdoctoral fellowship at the Centre for Discovery of Brain Sciences at the University of Edinburgh.
Teseo: Colom-Cadena M. Neuropathology of Lewy body diseases: confluence of multiple pathologies and role of synaptic phospho-alpha-synuclein. 2017