Our recent study shows that combining Array Tomography with an advanced imaging technique called Two-Colour Direct Stochastic Optical Reconstruction Microscopy (dSTORM) allows for the observation of tau pathology at synapses with unprecedented detail. This approach offers new insights into how these proteins disrupt brain function in Alzheimer’s disease (AD). What Was Done in This Study? … Read more
White matter hyperintensities (WMH) are one of the imaging biomarkers of small vessel disease of presumed vascular origin. These lesions can be shown as areas of increases signal on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging. WMH are frequently found in the elderly population and in both sporadic and genetic forms of Alzheimer’s disease (AD). … Read more
Anti-amyloid drugs have emerged as a promising treatment for Alzheimer’s disease. However, these treatments can potentially cause cerebral microbleeds – small brain bleeds that may occur when amyloid is cleared from blood vessels. Understanding the natural history of these microbleeds is crucial for safe patient treatment and monitoring. This study, published in Neurology, provides key … Read more
MRI and tauopathies Progressive supranuclear palsy (PSP) and Corticobasal Degeneration (CBD) are two subtypes of Frontotemporal Lobular Degeneration characterized by cerebral accumulation of tau protein (tauopathies). These diseases present classically with motor symptoms that include postural instability, difficulty in ocular movements, and limb control. However, in recent years it has been shown that they can … Read more
Víctor Montal Blancafort has presented today his Doctoral Thesis entitled “Complex neuroimaging changes in metabolite, cortical structures and regional vulnerabilities in the Alzheimer disease continuum“. The thesis, directed by Dr. Juan Fortea and supervised by Dr. Alberto Lleó, delves into new neuroimaging measures that help establishing the dynamic changes that occur throughout Alzheimer’s disease. Given … Read more
In January 18th 2022, Jordi Pegueroles Monllau presented his doctoral thesis entitled “The role of biomarkers in the current classification systems for Alzheimer’s Disease“. The thesis has been supervised by Dr. Juan Fortea and tutored by Dr. Alberto Lleó. This work has focused on the accuracy of different biomarkers of Alzheimer’s disease and their definition … Read more