A new publication led by the Sant Pau Memory Unit shows that microstructural changes of the cerebral cortex during the Alzheimer’s disease progression follow a biphasic model.
The collaboration between several Spanish centers (Hospital Universitario Marqués de Valdecilla from Santader and Fundación CITA-Alzheimer from San Sebastián), led by investigators from the Neuroimage group from the Sant Pau Memory Unit, has resulted in the publication “Cortical microstructural changes along the Alzheimer’s Disease continuum” in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, published online on October 25th.
This study is focused on the analysis of cortical thickness and mean difusivity in a group of 326 participants, through magnetic resonance imaging. During the early stages of Alzheimer’s disease, we observed an increase in the cortical thickness and a decrease in difusivity, probably due to inflammatory mechanisms. However, in advanced stages of the disease, the cortical thickness decreases and the mean difusivity increases, as a result of the neuronal loss.
More details about this article can be found in this Pubmed link.
Thanks for sharing this great article
buenas tardes: se han realizados estudios angiograficos de los microvasos a nivel cerebral ,asi como la angiografia que se realiza a nivel de la retina y que nos permita comparar estructuras normales con pacientes con la enfermedad en curso.
Gracias por el comentario. Este estudio se centró en cambios microestructurales corticales mediante resonancia magnética, y no incluyó angiografía cerebral ni comparaciones con estudios de retina. Sin embargo, el papel de los microvasos en el Alzheimer es un área activa de investigación a través de distintas técnicas, y enfoques como la OCT-angiografía retiniana están siendo explorados como posibles biomarcadores.