proNGF in Neuron-Derived Extracellular Vesicles: An Early Alzheimer’s Signature in Down Syndrome
proNGF in Neuron-Derived Extracellular Vesicles: An Early Alzheimer’s Signature in Down Syndrome Down syndrome (DS) is a genetic form of Alzheimer’s disease (AD), with a high risk of early-onset neurodegeneration. This study, published in Alzheimer’s & Dementia,...
Women show greater capacity to compensate for brain damage in cases of genetic frontotemporal dementia
Frontotemporal dementia (FTD) encompasses a diverse group of neurodegenerative diseases characterized by progressive deterioration in social behavior, language, and executive functions. This condition has a strong genetic basis, with up to 30% of affected individuals...
GFAP in plasma and CSF in Down syndrome and Alzheimer’s disease
Alzheimer’s Disease, Down Syndrome and GFAP People with Down syndrome are at higher risk of developing Alzheimer’s disease than the general population. In fact, by the age of 70, more than 95% of people with Down syndrome will develop Alzheimer’s...
Welcome to the team
Welcome! We would like to welcome the new members to the Memory Unit. Benjamin Buehner, is a german-canadian student who did his undergraduate degree in Biomedical Sciences at Queen’s University, in Canada. He is experienced on Sclerosis and...
Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist
Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and frontotemporal dementia, are a growing health concern worldwide, and their diagnosis and management are still challenging. However, recent advances in blood-based biomarkers...
Amyloid precursor protein βCTF accumulates in synapses in sporadic and genetic forms of Alzheimer’s disease
Amyloid precursor protein βCTF accumulates in synapses in sporadic and genetic forms of Alzheimer’s disease The main pathological features observed in a brain with Alzheimer’s disease (AD) are the accumulation of β-amyloid (Aβ) peptides in the form of plaques...
Bilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive Aphasia
Bilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive Aphasia Recent studies demonstrate that being bilingual can delay the onset of dementia by an average of 4-5 years. Stephanie Grasso (University of...
Enrichment of plasma-derived extracellular vesicles from astrocytes
Enrichment of plasma-derived extracellular vesicles from astrocytes Extracellular vesicles (EVs) are nanoparticles that are secreted by all cells in the body. EVs carries multiple cellular components, such as genetic material, proteins and lipid metabolites that often...