Dr. Alberto Lleó is the director of the Neurology Department at Hospital de la Santa Creu i Sant Pau.
After obtaining his Medical degree from the University of Barcelona, he completed his specialization in Neurology at Hospital de la Santa Creu i Sant Pau in 2000. Two years later, he obtained his PhD in Medicine at the University of Barcelona. After that, he continued his education with a clinical and basic research fellowship on memory and movement disorders at the Massachusetts General Hospital, Boston (2002-2004) where he combined clinical and research tasks.
In his professional career, Dr. Alberto Lleó has combined his clinical activity with translational research projects in the field of dementias, with a specific focus on the molecular bases of the disease and biomarker development. Some of his main contributions are the discovery of new genetic alterations in Alzheimer’s disease, the study of the gamma-secretase complex, and the assessment of new chemical biomarkers for Alzheimer’s disease and frontotemporal dementia.
Today, Dr. Alberto Lleó runs a translational group, leads many projects funded by public and private agencies, and collaborates regularly with numerous national and international research groups. He also coordinates the Alzheimer program of CIBERNED (Center for Networked Biomedical Research in Neurodegenerative Diseases). To date, he has authored more than 20 book chapters and over 150 publications in international journals, and his contributions have been awarded by the Spanish Society of Neurology.
Recent Publications
- Plasma proteome profiling identified biomarkers for the differential diagnosis and molecular staging of neurodegenerative dementias. Bellomo, G, Vermunt, L, In 't Veld, S et al. Nat Aging 2026PMID:42477094
- Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis. Blazhenets, G, Soleimani-Meigooni, DN, Chiotis, K et al. JAMA 2026PMID:42441390
- CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum. Arranz, J, Lantero-Rodríguez, J, Braun-Wohlfahrt, LS et al. EBioMedicine 2026PMID:42435584
- The predictive power of neuropsychological measures in MCI: early detection of dementia conversion. Padilla, C, Zsadanyi, SE, Aragón, I et al. Front Aging Neurosci 2026PMID:42404240
- Cerebrospinal fluid NPTX2/p-tau ratio as a biomarker for cognitive decline in neurodegenerative diseases. Gomes, BF, Sauer, M, Montoliu-Gaya, L et al. Alzheimers Dement (Amst) 2026PMID:42326467
- Clinical Impact and Prognostic Value of Alzheimer Disease Biomarkers in the Very Old. Ceriello, C, Torres, OH, Rubio-Guerra, S et al. Neurology 2026PMID:42308436
- Naming performance in bilinguals with Alzheimer's disease and mild cognitive impairment. Sainz-Pardo, M, Hernández, M, Suades, A et al. J Alzheimers Dis 2026PMID:42227174
- Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome-associated Alzheimer's disease. Morcillo-Nieto, AO, Franquesa-Mullerat, M, Zsadanyi, SE et al. Alzheimers Dement 2026PMID:42212383
- Characterizing circadian rest-activity rhythm patterns across Alzheimer's disease continuum in Down syndrome. Giménez, S, Vaqué-Alcázar, L, Clos, S et al. Alzheimers Dement 2026PMID:42056071
- GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy. Timsina, J, Jiang, C, McCartney, DL et al. Nat Commun 2026PMID:42014397
- An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration. Honey, MIJ, Hok-A-Hin, YS, Thijssen, EH et al. Nat Med 2026PMID:41986736
- Evidence for bilingualism as a cognitive reserve factor in biomarker-confirmed Alzheimer's disease. Grasso, SM, Bao, W, Marqués-Kiderle, SK et al. medRxiv 2026PMID:41959833
- Amyloid-linked versus age-driven copathologies in Alzheimer's dementia: differential associations with APOE ε4. Rodríguez-Baz, Í, Vaqué-Alcázar, L, Maure-Blesa, L et al. Res Sq 2026PMID:41890856
- Impaired semantic word learning in primary progressive aphasia. Olivé, G, Cardona, G, Porto, MF et al. Brain Struct Funct 2026PMID:41882244
- Bilingualism's protective effects in Alzheimer's disease: Mechanisms of resilience and resistance. Bao, W, Grasso, SM, Sala, I et al. medRxiv 2026PMID:41757199