Alberto Lleó Bisa

Alberto Lleó

Dr. Alberto Lleó is the director of the Memory Unit of the Neurology Department at Hospital de la Santa Creu i Sant Pau.

After obtaining his Medical degree from the University of Barcelona, he completed his specialization in Neurology at Hospital de la Santa Creu i Sant Pau in 2000. Two years later, he obtained his PhD in Medicine at the University of Barcelona and continued his education with a clinical and basic research fellowship on memory and movement disorders at the Massachusetts General Hospital, Boston (2002-2004) where he combined clinical and research tasks.

In his professional career, Dr. Alberto Lleó has combined his clinical activity with translational research projects in the field of dementias with a specific focus on the molecular bases of the disease and biomarker development. Some of his main contributions are the discovery of new genetic alterations in Alzheimer’s disease, the study of the gamma-secretase complex, and the assessment of new chemical biomarkers for Alzheimer’s disease and frontotemporal dementia.

Today, Dr. Alberto Lleó runs a translational group, leads many projects funded by public and private agencies, and collaborates regularly with numerous national and international research groups. He also coordinates the Alzheimer program of CIBERNED (Center for Networked Biomedical Research in Neurodegenerative Diseases). To date, he has authored more than 20 book chapters and over 150 publications in international journals, and his contributions have been awarded by the Spanish Society of Neurology.

Recent Publications

  1. Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome. Lleó, A, Zetterberg, H, Pegueroles, J et al. Nat Commun 2021

  2. Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome. Bejanin, A, Iulita, MF, Vilaplana, E et al. JAMA Neurol 2021

  3. VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome. Lleó, A, Carmona-Iragui, M, Videla, L et al. Alzheimers Res Ther 2021

  4. Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias. Alcolea, D, Delaby, C, Muñoz, L et al. J Neurol Neurosurg Psychiatry 2021

  5. A multicentre validation study of the diagnostic value of plasma neurofilament light. Ashton, NJ, Janelidze, S, Al Khleifat, A et al. Nat Commun 2021

  6. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. de Rojas, I, Moreno-Grau, S, Tesi, N et al. Nat Commun 2021

  7. State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease. Hampel, H, Shaw, LM, Aisen, P et al. Alzheimers Dement 2021

  8. TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels. Hong, S, Dobricic, V, Ohlei, O et al. Alzheimers Dement 2021

  9. Biomarkers in neurological disorders: a fast-growing market. Lleó, A Brain Commun 2021

  10. CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia. van der Ende, EL, Morenas-Rodriguez, E, McMillan, C et al. Neurobiol Aging 2021

  11. Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid. Boström, G, Freyhult, E, Virhammar, J et al. J Alzheimers Dis 2021

  12. AMYQ: An index to standardize quantitative amyloid load across PET tracers. Pegueroles, J, Montal, V, Bejanin, A et al. Alzheimers Dement 2021

  13. Replication study of plasma proteins relating to Alzheimer's pathology. Shi, L, Winchester, LM, Westwood, S et al. Alzheimers Dement 2021

  14. Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration. Illán-Gala, I, Falgàs, N, Friedberg, A et al. JAMA Netw Open 2021

  15. Race and Alzheimer Disease Biomarkers: A Neglected Race. Lleó, A, Suárez-Calvet, M Neurol Genet 2021

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